Pope Francis first appeared in St. Peter's Square in an open car on Sunday after recovering from the virus.
The head of the Catholic Church held a meeting with the faithful as part of the traditional program before the weekly angelus prayer of the Lord.
Pope Francis was seen in good spirits, he waved to the crowd and blessed them, demonstrating his closeness and accessibility to the people.
During the prayer, the Pope conveyed blessings and messages of peace, as well as expressing his support for those suffering from the war in Europe.
He also drew attention to the need for dialogue and cooperation among countries to solve common problems.